Osteoarthritis and Rheumatoid Arthritis VS NISSTEX
- xhteh9
- Nov 21
- 4 min read
Updated: Nov 24
Osteoarthritis is the most common form of arthritis, often referred to as a "wear and tear" disease.
It occurs when the cartilage that cushions the ends of bones in your joints gradually deteriorates, leading to pain, stiffness, and reduced mobility.
What Happens in Osteoarthritis?
Cartilage Breakdown: Cartilage acts as a shock absorber and allows smooth joint movement. In osteoarthritis, this cartilage wears away.
Bone-on-Bone Contact: Without cartilage, bones rub against each other, causing pain and inflammation.
Joint Changes: Osteoarthritis can lead to bone spurs, joint deformity, and changes in joint shape.
Causes and Risk Factors
Age: Risk increases with age.
Joint injury: Previous injuries can accelerate osteoarthritis.
Obesity: Extra weight stresses joints and promotes inflammation.
Genetics: Family history may increase risk.
Gender: Women are more likely to develop osteoarthritis.
Repetitive stress: Jobs or sports that overuse joints.
Treatment Options
While osteoarthritis cannot be cured, symptoms can be managed effectively:
MEDICATION
• Acetaminophen: For mild pain
• NSAIDs: Ibuprofen, Naproxen for inflammation and pain
• Topical NSAIDs: Applied directly to the skin.
• Duloxetine: Sometimes used for chronic pain
All the medications above comes with their own side effects, which in some cases are undesirable.
Rheumatoid Arthritis and Osteoarthritis
Osteoarthritis (OA) and Rheumatoid Arthritis (RA) are both common types of arthritis, but they
differ significantly in cause, symptoms, progression, and treatment.
Rheumatoid Arthritis requires immune-modulating treatment, while
Osteoarthritis is managed with lifestyle and pain control.
What Happens Inside the Body with Arthritis?
NORMAL JOINT ANATOMY
Joints are where two bones meet.
They are cushioned by cartilage, a smooth tissue that allows bones to glide over each other.
Synovial fluid lubricates the joint, and the synovium (lining) produces this fluid.
Ligaments and muscles support and stabilize the joint.
How Arthritis Develops
Osteoarthritis (OA) – Wear and Tear
Cartilage breaks down due to aging, overuse, or injury.
Bones begin to rub against each other, causing pain, stiffness, and swelling.
Bone spurs may form, and joint movement becomes limited.
Common in knees, hips, spine, and hands.
Rheumatoid Arthritis (RA) – Autoimmune Attack
The immune system mistakenly attacks the synovium.
This causes inflammation, swelling, and pain.
Over time, it can destroy cartilage and bone inside the joint.
RA is systemic, meaning it can affect other organs and cause fatigue, fever, and weight loss.
Gout – Crystal Build-Up
Excess uric acid forms sharp crystals in joints.
Causes sudden, severe pain and swelling, often in the big toe.
Psoriatic Arthritis – Linked to Psoriasis
Inflammation affects both skin and joints.
Can cause joint pain, stiffness, and swelling.
Infectious or Reactive Arthritis
Triggered by infections (e.g., chlamydia, salmonella).
Immune response causes joint inflammation.
FEATURES | OSTEOARTHRITIS (OA) | RHEUMATOID ARTHRITIS |
CAUSE | DEGENERATIVE JOINT DISEASE DUE TO WEAR AND TEAR | AUTOIMMUNE DISEASE WHERE THE IMMUNE SYSTEM ATTACKS JOINT LINING |
ONSET | GRADUAL, OVER YEARS | CAN DEVELOP QUICKLY, OVER WEEKS OR MONTHS |
AGE GROUP | COMMON IN OLDER ADULTS | CAN OCCUR IN ANY AGE, OFTEN IN MIDLIFE. |
AFFETCED JOINTS | OFTEN ONE SIDE OF THE BODY, KNEES, HIPS, SPINES, HANDS | SYMMETRICAL (BOTH SIDES) : FINGERS, WRISTS, KNEES, FEET
|
MORNING STIFFNESS | LAST < 30 MINUTES | LASTS > 1 HOUR |
OTHER SYMPTOMS | JOINT PAIN, STIFFNESS, CRACKING SOUNDS | FATUGUE, FEVER, WEIGHT LOSS, RHEUMATOID NODULES |
INFLAMMATION | MILD, LOCALIZED SIGNIFICANT | SYSTEMIC INFLAMMATION |
PROGRESSION | SLOW AND STEADY | CAN FLARE AND WORSEN RAPIDLY |
TREATMENT | PAIN RELIEF, PHYSICAL THERAPY, LIFESTYLE CHANGES | IMMUNOSUPPRESSANTS, BIOLOGICS, ANTI-INFLAMMATORIES |
How NISSTEX Works
The main active compound in black seed is Thymoquinone, which has anti-inflammatory, anti-oxidant, and immunomodulatory properties:
b) Black seed compounds help protect cartilage and reduce nitric oxide production, slowing joint destruction.
Anti - Oxidant Action
a) Neutralizes free radicals that worsen joint damage.
b) Supports natural antioxidant defenses to prevent oxidative stress.
Immune System Modulation
a) RA is an autoimmune disease; black seed helps balance immune response, reducing abnormal attacks on joints.
Black seed (Nigella sativa) and NISSTEX, which is a scientifically formulated black seed based
product, can help in osteoarthritis and rheumatoid arthritis through several mechanisms:
✅ Evidence for Osteoarthritis
•Clinical trials show Nigella sativa can reduce pain intensity and improve quality of life in OA parents.
•It acts as a safe adjuvant therapy, with chondroprotective effects (protecting cartilage) and fewer side effects compared to NSAIDs.
✅ Evidence for Rheumatoid Arthritis
•Studies indicate black seed oil suppresses inflammatory pathways and may help reduce disease activity when combined with standard RA medications.
•It does not replace DMARDs or biologics, but can complement them for better symptom.
✅ Role of NISSTEX
•Nisstex enhances these benefits by using precise concentrations of Nigella sativa and
synergistic herbal components, processed for maximum bioavailability and zero side effects.
•It targets chronic inflammation, supports immune regulation, and may help reduce pain
and stiffness in arthritis patients.
Main Advantages of NISSTEX
🌿No side effects
Safe for regular use, including for children.
🌿Easily Absorbed
Chewable form allows rapid absorption in the oral cavity.
🌿Easy & Convenient
No need for water or swallowing large pills.
Recommended Dosage
1 to 2 chewable tablets daily, preferably taken after meals or as advised by a healthcare provider.
Place a tablet in the mouth and allow it to dissolve completely. No need to chew or swallow.
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